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Home page > Séminaires > Archives séminaires > Séminaires 2019 > Séminaire MSC. 17 décembre 2019. Luca Boselli (University College Dublin) : "Plasmonic hybrid nanosystems with multiple shapes for biomedical applications.."".

Séminaire MSC. 17 décembre 2019. Luca Boselli (University College Dublin) : "Plasmonic hybrid nanosystems with multiple shapes for biomedical applications..""

Sauf mention contraire, les séminaires et les soutenances se déroulent à 11h30 en salle 454A du bâtiment Condorcet.

Séminaire annulé / Seminar cancelled

Exceptional schedule Tuesday December 17th 11h30 room 454 A.

Plasmonic hybrid nanosystems with multiple shapes for biomedical applications

Dr. Luca Boselli

Postodoctoral fellow at Centre for Bionano Interactions

University College Dublin (UCD), Ireland

Abstract :
Nanomedicine aims to exploit engineered nanoparticles (NPs) presenting different size, shape, and surface chemistry to interact with specific biological targets inducing unique responses. The choices in NPs types are nowadays so extensive to be almost limitless. The NPs shape has shown to play a relevant role in driving biological processes and being able to capture and quantify shape control parameters on a scale that is meaningfully related to the biology is an urgent requirement. However, from the synthetic point of view, there is still a lack of a complete understanding on how these shape features are generated and, especially for complex nanostructures (i.e. branched NPs) the synthesis still suffer of high in-batch and batch-to-batch variability both in terms of size and shape distribution therefore limiting the translation of these materials to biomedical applications. Furthermore, there is actually no effective characterisation tool used to distinguish and classify irregular complex shape and it is therefore very challenging to clearly correlate geometrical parameters to biological impacts. Despite the great potential shown by nanomedicine, only few examples of nanosystems have led so far to truly successful clinical results due to the difficulties in driving nano-bio interactions in complex biological environments. When NPs come in contact with biological milieu, various biomolecules adsorb on its surface, leading to the formation of the so called “biomolecular corona” which can alter the biological fate of the NPs. In this presentation, promising approaches aiming to improve the control over the synthesis and biological identity of plasmonic complex gold nanostructures are discussed. In particular, we propose the use of microfluidic synthesis in continuous flow to generate high quality and reproducible branched gold NPs with minimum human interference, coupled with a computational approach to objectively characterize their shape. Then, in order to guarantee to the NPs a recognizable bio-identity which remains functional in real biological conditions, we adopted a biomimetic approach, functionalizing plasmonic particles with nanosized natural cellular membranes. These hybrid nanomaterials were characterised to show the effective complexation NP-cell membrane and their reconition in flow.

Contact : Équipe séminaires / Seminar team - Published on / Publié le 9 décembre 2019

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