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Home page > Seminars > Séminaires théorie > Theory Club Monday February 24 2020 at 12:00 in room 412B. Efe Ilker: "Controlling the dynamics of populations in biology, from proteins to ecological populations".

Theory Club Monday February 24 2020 at 12:00 in room 412B. Efe Ilker: "Controlling the dynamics of populations in biology, from proteins to ecological populations"

Unless otherwise stated, seminars and defences take place at 11:30 in room 454A of Condorcet building.


Controlling the dynamics of populations in biology, from proteins to ecological populations

Efe Ilker

Abstract: Real-time control of a system with inherently stochastic processes requires nonequilibrium driving. However, the actual system always lags behind the desired state due to information loss, which for thermodynamic systems is in the form of dissipation. Generally, the time evolution of the system can be directly controlled by very slow (adiabatic) driving but speed is essential in many biological processes. Then, how can we compensate to move the system along a controlled trajectory in a finite time? Can we find protocols to assist this driving via an auxiliary field which would always keep the system on the desired trajectory? 

In this talk, I will present a method to control the set of trajectories in stochastic networks that has close analogies with quantum adiabatic protocols (transitionless quantum driving). We will explore the implementation of these ideas with two example applications in biology: i) the evolution of populations under selective pressure and ii) in the context of protein folding biophysics. In the first example, I will show how to manipulate the evolutionary dynamics of cell populations by dosage control of drugs. This could have wide potential applications, from therapeutic strategies against complex diseases to crop design.  In the second example, we will discuss an already adapted driving protocol as a response to heat shock by molecular chaperones acting as recovery agents for misfolded proteins in cells.

Monday February 24 at 12:00 in room 412B


Contact : Équipe séminaires / Seminar team - Published on / Publié le 21 February 2020


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