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Accueil du site > Séminaires > Séminaires 2020 > Visio-Séminaire MSC. 25 Mai 2020 14h. Philippe Marcq (PMMH, Paris) : "Forces and stresses in epithelial monolayers ".

Visio-Séminaire MSC. 25 Mai 2020 14h. Philippe Marcq (PMMH, Paris) : "Forces and stresses in epithelial monolayers "

Sauf mention contraire, les séminaires et les soutenances se déroulent à 11h30 en salle 454A du bâtiment Condorcet.


Video Seminar. Monday 25th May 14h00 Contact Michael Berhanu to attend the video seminar.

Forces and stresses in epithelial monolayers

Philippe Marcq

Sorbonne Université — Laboratoire Physique et Mécanique des Milieux Hétérogènes, ESPCI, Paris

The mechanical behavior of living tissues is deeply connected with many important biophysical questions, yet little is known about internal tissue mechanics. Since the traction forces exerted by cells on a planar, deformable substrate can be measured, we combine traction force data with Bayesian inversion to estimate the internal stress field of a cell epithelial monolayer. The method is validated using numerical simulations as well as experimental data. Importantly, its accuracy does not depend on the rheology of the tissue. Given traction force timelapse movies, we show that the tissue stress field can also be estimated by Kalman filtering. Inferred stresses allow to quantify the rheology of epithelial cell sheets in physiological conditions. In a tissue where cell rearrangements are rare, we find that cell shape anisotropy is a good proxy for deviatoric stress.


Contact : Équipe séminaires / Seminar team - Published on / Publié le 18 mai


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