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Home page > Séminaires > Séminaires 2021 > 11 janvier 2021, 11h30, Séminaire MSC, J-B. Manneville, Institut Curie, "Intracellular mechanics of normal and cancer cells".

11 janvier 2021, 11h30, Séminaire MSC, J-B. Manneville, Institut Curie, "Intracellular mechanics of normal and cancer cells"

Sauf mention contraire, les séminaires et les soutenances se déroulent à 11h30 en salle 454A du bâtiment Condorcet.


Intracellular mechanics of normal and cancer cells

Le lundi 11 janvier 2021 à 11h30, sur ZOOM, bât Condorcet

Jean-Baptiste Manneville, Institut Curie

Mechanotransduction, which allows cells to sense and respond to external forces, has essentially been studied at the plasma membrane or at the nucleus. However, how forces are transmitted from the outside to the cell interior and how intracellular mechanotransduction is altered in pathological contexts such as cancer is still poorly understood. We are investigating the roles of the mechanics of the cytoplasm and the cytoskeleton in transmitting external forces to intracellular organelles, including the nucleus and the Golgi apparatus. During this seminar, I will discuss the results we obtained using intracellular optical tweezers-based microrheology, both in normal and cancer cells. I will give an overview of three aspects of our recent research. First, I will show that cell mechanics can discriminate between glioma cells of different grades, and that the cytoskeleton and the nucleus contribute to the observed differences. Then, I will show that the Golgi apparatus is able to sense external forces and responds by modulating post-Golgi membrane trafficking. Finally, I will focus on the mechanical links between the microtubule and intermediate filament cytoskeletons to highlight their potential roles in intracellular mechanotransduction.


Contact : Équipe séminaires / Seminar team - Published on / Publié le 4 janvier