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Home page > Séminaires > Séminaires 2021 > MSC Visio-Seminar. Postponed. Catherine Villard (Institut Curie & institut Pierre Gilles de Gennes) : "Fungi under confined space : a biophysical approach of the filamentous yeast Candida albicans".

MSC Visio-Seminar. Postponed. Catherine Villard (Institut Curie & institut Pierre Gilles de Gennes) : "Fungi under confined space : a biophysical approach of the filamentous yeast Candida albicans"

Sauf mention contraire, les séminaires et les soutenances se déroulent à 11h30 en salle 454A du bâtiment Condorcet.


There will be a live diffusion with Zoom.

Postponed to a later date

Fungi under confined space : a biophysical approach of the filamentous yeast Candida albicans

Catherine Villard

Institut Curie UMR 168 CNRS – Institut Pierre Gilles De Gennes (IPGG) pour la microfluidique

Abstract : Fungi are present everywhere in the biosphere of our planet, from marine to terrestrial ecosystems. Their morphological polymorphism, i.e. their ability to grow as yeast or as long polynucleated filaments named hyphae, is instrumental in their ability to colonize their environments. They combine different lifestyles - saprophytic, pathogenic or symbiotic, and interact massively with most of the organisms composing the tree of life.

I will present a few facets of a specific fungus, Candida albicans, a rare member of the human commensal microbiota in its yeast form, which can also turn into an invasive opportunistic pathogen in immunocompromised individuals thanks to its yeast-to-hypha polymorphism.

C. albicans colonization of a tissue occurs in an inherent context of confinement. To dissect the impact of this physical constraint on different aspects of C. albicans physiology, we have developed dedicated microfluidic microenvironments such as compression chambers and microchannels of different geometries. I will give some insights about yeasts-to-hyphae (and hyphae-to-yeasts) transformation and hyphal exploration modalities (which turns to be oscillatory) induced by cell-cell or cell-substrate contact forces arising from confinement.

I will conclude on some possible openings in fungi research addressing e.g. the issue of polymorphism and cell cycle in yeasts living in extreme environments such as deep-sea hydrothermal vents or brine waters.


Contact : Équipe séminaires / Seminar team - Published on / Publié le 5 juillet


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