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Home page > Séminaires > Archives séminaires > Séminaires 2021 > MSC Visio-Seminar. December 6th 2021. Mechanics , (Institut Curie) : "Mechanics and polarity in B cells".

MSC Visio-Seminar. December 6th 2021. Mechanics , (Institut Curie) : "Mechanics and polarity in B cells"

Sauf mention contraire, les séminaires et les soutenances se déroulent à 11h30 en salle 454A du bâtiment Condorcet.

Monday December 6th, 11h30 There will be a live diffusion with Zoom.

Mechanics and polarity in B cells

Paolo Pierobon

Spatio temporal dynamics of immune cell, Inserm U932, Institut Curie

B cells are the antibody producing cells of immune system. To mount an efficient immune response, B cells recognize and internalize the antigen through a specific signaling platform called immune synapse. The formation of such a structure entails force generation and polarization of cellular structures that we have studied in details in the past years. Recently, we used functionalized microdroplets as presenting-cell models and a microfluidic pairing device to observe multiple synchronized synapses. This system allowed us to understand the role of the different physico-chemical properties of the presenting surface in polarity. We also identified an early and a late phases in polarity dominated, respectively, by actin and microtubules dynamics and further highlight an unexpected role for microtubules in restricting F-actin polymerization to allow the formation and maintenance of a unique immune synapse.

Contact : Équipe séminaires / Seminar team - Published on / Publié le 2 décembre 2021

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