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Home page > Seminars > Séminaires théorie > Theory Club on Tuesday March 8th, 2022 at 10.30 am (room 646A). Ram Adar : "Active-gel Theory for Multicellular Migration in the Extra-cellular Matrix"..

Theory Club on Tuesday March 8th, 2022 at 10.30 am (room 646A). Ram Adar : "Active-gel Theory for Multicellular Migration in the Extra-cellular Matrix".

Unless otherwise stated, seminars and defences take place at 11:30 in room 454A of Condorcet building.


Speaker: Ram M. Adar ( College de France and Institut Curie)

Title: Active-gel Theory for Multicellular Migration in the Extra-cellular Matrix

Abstract: We formulate an active-gel theory for multicellular migration in the extracellular matrix (ECM). The cells are modeled as an active, polar solvent, and the ECM as a viscoelastic solid. Our theory enables to analyze the dynamic reciprocity between the migrating cells and their environment in terms of distinct relative forces and alignment mechanisms. We analyze the linear stability of polar cells migrating homogeneously in the ECM. Our theory predicts that, as a consequence of cell-matrix alignment, contractile cells migrate homogeneously for small wave vectors, while sufficiently extensile cells migrate in domains. Homogeneous cell migration of both extensile and contractile cells may be unstable for larger wave vectors, due to active forces and the alignment of cells with their concentration gradient. These mechanisms are stabilized by cellular alignment to the migration flow and matrix stiffness. They are expected to be suppressed entirely for rigid matrices with elastic moduli of order 10 kPa. Our theory should be useful in analyzing multicellular migration and ECM patterning at the mesoscopic scale.


Contact : Équipe séminaires / Seminar team - Published on / Publié le 11 February


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