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Accueil du site > Séminaires > Séminaires 2022 > MSC Seminar. March 21st 2022 at 11:30. Olivier Theodoly (Laboratoire Adhésion et Inflammation, Marseille) : "Migration of immune cells in vitro : mechanisms of propulsion and guidance" .

MSC Seminar. March 21st 2022 at 11:30. Olivier Theodoly (Laboratoire Adhésion et Inflammation, Marseille) : "Migration of immune cells in vitro : mechanisms of propulsion and guidance"

Sauf mention contraire, les séminaires et les soutenances se déroulent à 11h30 en salle 454A du bâtiment Condorcet.


There will be a live diffusion with Zoom.

Monday March 21st, 11h30

Contact Jean-Baptiste Manneville to attend the visio-seminar

Migration of immune cells in vitro : mechanisms of propulsion and guidance

Olivier Théodoly

Laboratoire Adhésion et Inflammation, INSERM U1067, CNRS UMR7333, AMU U61, Campus de Luminy, Marseille

Abstract : Immune cells, or leukocytes, are responsible for the main defenses of our organism against infections. Upon recruitment from blood, leukocytes crawl on blood vessel walls and migrate into inflamed tissues under the guidance of chemical and mechanical stimuli. We present here some achievements to decipher the mechanisms of leukocyte propulsion and guidance with the use of reductionist in vitro tools and primary human lymphocytes. Concerning propulsion, mammalian cells usually need adhesion or friction with a substrate to move. We will show here that lymphocytes can swim and we propose a new mechanism of molecular paddling. Concerning guidance, we present new phenotypes of mechanical guidance by flow and chemical guidance by adhesion molecules, and we discuss their active or passive nature.


Contact : Équipe séminaires / Seminar team - Published on / Publié le 10 mars


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