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Home page > Séminaires > Séminaires 2022 > 15 novembre 2022, 14h00, 646A, Séminaire MSC, Maximé Mahé, INSERM "Manipulating pluripotent stem cells to generate human intestine".

15 novembre 2022, 14h00, 646A, Séminaire MSC, Maximé Mahé, INSERM "Manipulating pluripotent stem cells to generate human intestine"

Sauf mention contraire, les séminaires et les soutenances se déroulent à 11h30 en salle 454A du bâtiment Condorcet.


Manipulating pluripotent stem cells to generate human intestine

Abstract :

The use of pluripotent and adult stem cells is paving the way for probing human physiopathology and finding new treatments. Using the intestine as an example, I will highlight how we can use stem cells in addition to 3D integrated organoid model systems to engineer tissue and how we can use these models to comprehend tissue morphogenesis and diseases.

Bio :

In 2012, Dr. Maxime Mahe obtained his Ph.D. from the University of Nantes in Neurogastroenterology. In 2012, he joined the Division of Pediatric General and Thoracic Surgery at CCHMC, under the leadership of Michael Helmrath, MD, MS and Jim Wells, Ph.D., and worked on developing new methodologies for studying murine and human intestinal stem cells. My research aimed to create and use intestinal stem cell culture techniques to study the mechanisms that result in regional-specific intestinal stem cell patterning. They were the first group to successfully generate 3-dimensional intestinal human PSCs and show functional maturation following engraftment into mice to study regional patterning in the small intestine. In 2017, Dr. Mahe was recruited as an assistant professor (Inserm CRCN) to establish a research program on the effects of the enteric nervous system on intestinal development using innovative approaches.


Contact : Équipe séminaires / Seminar team - Published on / Publié le 14 novembre 2022


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