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Accueil du site > Séminaires > Archives séminaires > Séminaires 2010 > Séminaire MSC 08 nov. 2010 à 11h30. Fabien Montel (Institut Curie) : "Tumor and microenvironement : the role of pressure in cancer proliferation".

MSC Seminar 2010 Nov. 08 at 11:30. Fabien Montel (Institut Curie) : "Tumor and microenvironement : the role of pressure in cancer proliferation"

Unless otherwise stated, seminars and defences take place at 11:30 in room 454A of Condorcet building.

Cancer progress is a multistep process. In the case of carconimas the primary tumor growth locally before some cells evade the stroma by degrading the basal membrane. Two main elements drive the primary tumor proliferation : accumulation of genetic aberrations and the tumoral micro-environment. In contrast with the genetic aberrations, the precise role of the micro-environment and its interplay with the tumor is still poorly understood. Recent works suggest that the mechanical pressure felt by the tumor and the stroma can play a role in the tumor progression. In this project we study the physical and biological interplays of the tumor and its micro-environment focusing on the role of the mechanical stress. We present two different approaches to measure the effect of pressure on tissue growth and death. The first setup use osmotic pressure to deform a dialysis bag and exert a known pressure on a multicellular tumor spheroid. First results indicate the ability to modulate tumor growth depending on the applied pressure. The second setup is a microfluidic based integrated system which enables to feed and visualize spheroids in the same time that we apply a known pressure.

Contact : Équipe séminaires / Seminar team - Published on / Publié le 25 October 2010