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Home page > Séminaires > Archives séminaires > Séminaires 2012 > Séminaire MSC lundi 17 septembre 2012 à 11h30. W. James Nelson (Stanford) : Structural and Functional Evolution of Epithelia and Cell-Cell Adhesion Complexes.

Séminaire MSC lundi 17 septembre 2012 à 11h30. W. James Nelson (Stanford) : Structural and Functional Evolution of Epithelia and Cell-Cell Adhesion Complexes

Sauf mention contraire, les séminaires et les soutenances se déroulent à 11h30 en salle 454A du bâtiment Condorcet.


Structural and Functional Evolution of Epithelia and Cell-Cell Adhesion Complexes

W. James Nelson, Department of Biology, The James H. Clark Center, The Bio-X Program, Stanford University, California USA

(webpage)

Attention lieu exceptionnel : Amphithéâtre Pierre-Gilles de Gennes du Bâtiment Condorcet (niveau -1).

A tube surrounded by a simple layer of cells, called an epithelium, is the most basic tissue organization in animals. Epithelial organization, which requires cadherin-catenin cell adhesion complexes that glue cells together and organize the interior cytoskeleton of the cells, is thought to have evolved at the time animals first appeared, about 600 million years ago. I will show that an epithelial tube occurs in organisms that are much more primitive than animals, and that the mechanisms involved are similar to those in animals. Detailed biochemical analysis of cadherincatenin complexes reveals increased complexity in mechanisms regulating cell-cell adhesion and actin cytoskeleton interactions during evolution. These studies demonstrate an evolutionarily conserved mechanisms involved in cell-cell adhesion and tissue organization that may have originated >1 billion years ago.


Contact : Équipe séminaires / Seminar team - Published on / Publié le 26 juillet 2012


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