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Home page > Séminaires > Archives séminaires > Séminaires 2012 > ATTENTION : Séminaire MSC à 10h ! lundi 3 décembre 2012. Yariv Kafrif (Technion - Israel Institute of Technology), biophysics/statistical mechanics..

ATTENTION : Séminaire MSC à 10h ! lundi 3 décembre 2012. Yariv Kafrif (Technion - Israel Institute of Technology), biophysics/statistical mechanics.

Sauf mention contraire, les séminaires et les soutenances se déroulent à 11h30 en salle 454A du bâtiment Condorcet.


ATTENTION AU CHANGEMENT D’HEURE. séminaire à 10h ! en 454A

Classes of fast and specific search mechanisms for proteins on DNA

JPEG - 51.4 ko

Problems of search and recognition appear over different scales in biological systems. The talk will focus on the challenges posed by interactions between proteins, in particular transcription factors, and DNA and possible mechanisms which allow for a fast and selective target location. Initially it will be argued that DNA-binding proteins can be classified, broadly, into three distinct classes which we illustrate using experimental data. The classification is directly related to the binding energy landscape of the proteins to the DNA. Each class calls for a different search process and we discuss the possible application of different search mechanisms proposed over the years to each class. Time permitting I will also discuss a new barrier controlled search mechanism as well as the non-trivial influence of the binding energy landscape on the Hill coefficient of transcription factors.


Contact : Équipe séminaires / Seminar team - Published on / Publié le 22 novembre 2012


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