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Home page > Séminaires > Archives séminaires > Séminaires 2013 > Séminaire MSC lundi 27 Mai à 11h30. Xavier Darzacq. "Single molecule tracking reveals guiding mechanisms".

Séminaire MSC lundi 27 Mai à 11h30. Xavier Darzacq. "Single molecule tracking reveals guiding mechanisms"

Sauf mention contraire, les séminaires et les soutenances se déroulent à 11h30 en salle 454A du bâtiment Condorcet.


While membranes do not compartmentalize the nucleus, it shows a complex organization at many scales. Because spatial organization of chromatin and transcription factors can modulate nuclear functions, we have developed methods to study proteins and mRNAs at the single molecule level and with spatial resolutions in the range of a few nanometers (modifications and improvements of PALM, sptPALM and STORM). Moreover, proteins move throughout the nucleus by diffusion, transiently and repetitively contacting their target sites. While DNA has been reported as a guide facilitating target search in the cell by restricting 3 dimensional explorations to a 1 dimensional search, such exploration modes were not envisioned for proteins. I will discuss chromatin and RNA polymerase II organization in the nucleus as well as mechanisms guiding proteins to their targets in the nucleoplasm.


Contact : Équipe séminaires / Seminar team - Published on / Publié le 22 mars 2013


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