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На главную > Séminaires > Archives séminaires > Séminaires 2014 > Séminaire MSC. Lundi 24 novembre 2014. Serena Bradde : "Cell size control in bacteria" .

Séminaire MSC. Lundi 24 novembre 2014. Serena Bradde : "Cell size control in bacteria"

Sauf mention contraire, les séminaires et les soutenances se déroulent à 11h30 en salle 454A du bâtiment Condorcet.


Cell size control in bacteria

Serena Bradde (City University of New York)

How cells control their size is a fundamental question in biology. Textbook hypotheses focus on mechanisms for sensing size, time, or a combination of the two, based on classical correlation studies of the model bacterium Escherichia coli. However, experimental evidence supporting either model was lacking due to the inability to assess the impact of changes in size on single cells in real time. In this talk I will present all possible mechanisms in details. By analysing fluctutations in physiological properties of division of hundreds of thousands of Gram-negative E. coli and Gram-positive B. subtilis cells under a wide range of tightly controlled steady-state growth conditions, we are now in the position to validate different theoretical models. The results demonstrate a strikingly simple mechanism whereby cells sense neither time nor space, but add a constant volume each generation irrespective of their newborn sizes. This general mechanism quantitatively explains all measurable aspects of growth and cell division at both population and single-cell levels, including the origin and the hierarchy of variability in the underlying size-control mechanisms.


Contact : Équipe séminaires / Seminar team - Published on / Publié le 3 octobre 2014


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