Home page > Séminaires > Séminaire des doctorants > Mercredi 15 juin : Emilie Mathieu (Laboratoire des biomolécules - ENS Paris) "Manganese SOD mimics showing an anti-inflammatory activity on a cellular model of Inflammatory Bowel Diseases".
Mercredi 15 juin : Emilie Mathieu (Laboratoire des biomolécules - ENS Paris) "Manganese SOD mimics showing an anti-inflammatory activity on a cellular model of Inflammatory Bowel Diseases"
Sauf mention contraire, les séminaires et les soutenances se déroulent à 11h30 en salle 454A du bâtiment Condorcet.
Manganese SOD mimics showing an anti-inflammatory activity on a cellular model of Inflammatory Bowel Diseases
Emilie Mathieu (Laboratoire des biomolécules - ENS Paris)
Mercredi 15 juin, à 18h, en 646A.
Oxidative stress has been identified as an important event implicated in several diseases ranging from inflammatory diseases to neurodegeneration or cancer. It occurs when reactive oxygen species (superoxide, hydrogen peroxide, hydroxyl radical) production overwhelms cells endogenous antioxidant defenses.
SuperOxide Dismutases (SOD) are a family of metallo-enzymes implicated in the reduction of oxidative stress and inflammation process by tightly controlling the concentration of superoxide in cells. The therapeutic use of purified SOD has been envisioned but is limited by a poor cell penetration of the enzyme, and immunogenicity problems. To overcome these drawbacks small complexes mimicking the activity of SODs have been designed and their activity has been studied on models ranging from prokaryotic cells to mices.
The challenge is now to understand at the molecular scale their mechanism of action in cells, and thus to answer the question of the bioavailability of such complexes.
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Contact : Équipe séminaires / Seminar team - Published on / Publié le 14 juin 2016
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