Partenaires

MSC
Logo CNRS Logo Université Paris Diderot
Logo tutelle Logo tutelle



Search

On this website

On the whole CNRS Web


Home page > Séminaires > Archives séminaires > Séminaires 2017 > Séminaire MSC. 13 mars 2017. Georges Debregeas (Jean Perrin,UPMC) : "Sensorimotor neural computation underlying phototaxis in zebrafish.".

Séminaire MSC. 13 mars 2017. Georges Debregeas (Jean Perrin,UPMC) : "Sensorimotor neural computation underlying phototaxis in zebrafish."

Sauf mention contraire, les séminaires et les soutenances se déroulent à 11h30 en salle 454A du bâtiment Condorcet.


Sensorimotor neural computation underlying phototaxis in zebrafish

Georges Debrégeas

Laboratoire Jean Perrin, UMR 8237 UPMC/CNRS

The zebrafish larva combines several assets – transparency, small brain dimensions, genetic tractability – that makes it a unique model system for whole-brain functional imaging. Using high-speed light-sheet microscopy, it is now possible to simultaneously record the activity of the quasi-entirety of the larva brain in vivo at single cell resolution. I will illustrate the potential of such a brain-scale approach for the study of the neuronal basis of sensorimotor integration. By correlating neural activity with gaze orientation, we were able to identify a circuit in the hindbrain that acts as a pacemaker for spontaneous eyes saccades. We further showed that the circuit is a substrate for visual integration. Its interaction with the visual pathway however differs from a simple stimulus-response pattern. Visual stimuli exert an action that depends on the circuit oscillatory phase at which they are delivered, a mechanism that manifests itself in its phase-locked entrainment by periodic stimuli. I will discuss how this circuit may subserve phototaxis, i.e. the spontaneous navigation of larvae towards illuminated regions.


Contact : Équipe séminaires / Seminar team - Published on / Publié le 9 décembre 2016


Dans la même rubrique :