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Accueil du site > Annuaire > BERRET Jean-François > 2017 PhD research topic - Rheology and microfluidics of lung lining fluids: the cases of mucus and of pulmonary surfactant.

2017 PhD research topic - Rheology and microfluidics of lung lining fluids: the cases of mucus and of pulmonary surfactant

2017 PhD research topic

Understanding the impact distribution of particles entering the human respiratory system is of primary importance as it not only concerns atmospheric pollutants, dusts or pathogens of various kinds, but also the efficiency of aerosol therapy and drug delivery. The goal of this project is to study the mechanical and rheological properties of lung lining fluids under healthy and pathological conditions. These fluids are the mucus in the conductive zone and as the pulmonary surfactant in the respiratory zone. They are secreted by the lung epithelium and are the first barrier against pathogens and particles. The results will allow predicting the fluid transport processes in lungs and will help in determining new diagnosis and therapeutic procedures, in particular in case of acute respiratory distress syndrome. The project aims to study the rheological properties of mucus and surfactant lung fluids using advanced microfluidic and microrheology techniques. New microrheology methods based on the use of rotating magnetic wires will be applied. 3D Magnetic Resonance Imaging will be used to investigate the complex flow of these fluids in model lungs with fractal arborescence. Lung fluids altered chemically by the presence of inhaled particles or biologically by addition of drugs will be investigated.

Keywords

Biophysics, Magnetic particles, liquids or materials, responsive materials, Microfabrication, Nanoparticles, Medical applications, biomaterials, biomimicry, BERRET Jean-François, Proposition de stage ou de thèse, ANR, 518, 107, Ancienne proposition


Contact : Published on / Publié le 23 March 2017