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Accueil du site > Seminars > Séminaires théorie > Theory Club Wednesday the 4 of October à 12:00pm en salle 646A. Sham Tlili: "Interplay between mechanical forces and cell differentiation in the zebrafish myotome morphogenesis".

Theory Club Wednesday the 4 of October à 12:00pm en salle 646A. Sham Tlili: "Interplay between mechanical forces and cell differentiation in the zebrafish myotome morphogenesis"

Unless otherwise stated, seminars and defences take place at 11:30 in room 454A of Condorcet building.


Interplay between mechanical forces and cell differentiation in the zebrafish myotome morphogenesis

Sham Tlili

Abstract:

PNG - 1.6 Mb

Somitic muscle segments of zebrafish exhibit V-shaped structures, called chevrons, which arebelieved to play a role in swimming. However, the mechanism that drives robust chevron patterning and shaping during embryogenesis remains elusive. In the developing zebrafish embryo, future muscle segments(somites) are generated as elliptical blobs that mature and spread to acquire their final chevron shape. Combining single-cell resolution microscopy and theoretical modelling we investigate the interplay between intrinsic (cellular reorganization within the somite tissue, such as cell rearrangements and cell differentiation) and extrinsic (coupling with neighbouring tissues) factors. We use live confocal imaging to follow the evolution of the three-dimensional shape of somites and Particle Image Velocimetry to quantify the relative tissue movements. We encompass our experimental observations in a vertex model that combines tissue differential growth, cell division and rearrangements with anisotropic elongation due to cell differentiation. By exploring the range of the model parameters, we construct a phase diagram of the final somite shape and study in particular the stability of the chevron shape.

Wednesday the 4 of October at 12:00pm in room 646A


Contact : Équipe séminaires / Seminar team - Published on / Publié le 20 September 2017


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