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Accueil du site > Seminars > Séminaires 2017 > 18 décembre 2017. Pierre Sens (Institut Curie): "Mechano-sensitive adhesion in cell spreading and crawling".

18 décembre 2017. Pierre Sens (Institut Curie): "Mechano-sensitive adhesion in cell spreading and crawling"

Unless otherwise stated, seminars and defences take place at 11:30 in room 454A of Condorcet building.

Mechano-sensitive adhesion in cell spreading and crawling

Pierre Sens

Institut Curie - Physico Chimie Curie Lab

Abstract: Crawling cell motility relies on active mechanical forces generated by the cell cytoskeleton, and the transmission of these forces via adhesion molecules linking the cell to a substrate. When moving over a flat and rigid substrate, cells usually develop thin and broad protrusions at their front, called lamellipodia, where actin polymerisation generates a protrusive force pushing the front edge of the cell forward. The lamellipodium displays interesting dynamics, including normal and lateral waves, possibly relevant to cell polarisation and the initiation of motion.

JPEG - 19.7 kb

I will discuss a stochastic model of mechano-sensitive cell adhesion, and discuss its relevance for symmetry breaking, cell polarisation, and motility. I will then discuss a generic model of micro-crawlers, built as an extension of low Reynolds number micro-swimmers, that highlights the crucial role of mechano-sensitive adhesion for the active crawling of cells and biomimetic objects.

Contact : Équipe séminaires / Seminar team - Published on / Publié le 22 November

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