Startseite > Seminars > Previous seminars > Séminaires 2017 > 18 décembre 2017. Pierre Sens (Institut Curie): "Mechano-sensitive adhesion in cell spreading and crawling".
18 décembre 2017. Pierre Sens (Institut Curie): "Mechano-sensitive adhesion in cell spreading and crawling"
Unless otherwise stated, seminars and defences take place at 11:30 in room 454A of Condorcet building.
Mechano-sensitive adhesion in cell spreading and crawling
Institut Curie - Physico Chimie Curie Lab
Abstract: Crawling cell motility relies on active mechanical forces generated by the cell cytoskeleton, and the transmission of these forces via adhesion molecules linking the cell to a substrate. When moving over a flat and rigid substrate, cells usually develop thin and broad protrusions at their front, called lamellipodia, where actin polymerisation generates a protrusive force pushing the front edge of the cell forward. The lamellipodium displays interesting dynamics, including normal and lateral waves, possibly relevant to cell polarisation and the initiation of motion.
I will discuss a stochastic model of mechano-sensitive cell adhesion, and discuss its relevance for symmetry breaking, cell polarisation, and motility. I will then discuss a generic model of micro-crawlers, built as an extension of low Reynolds number micro-swimmers, that highlights the crucial role of mechano-sensitive adhesion for the active crawling of cells and biomimetic objects.
Contact : Équipe séminaires / Seminar team - Published on / Publié le 22 November 2017
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