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Accueil du site > Séminaires > Archives séminaires > Séminaires 2017 > 4 décembre 2017. Jean-Léon Maitre (Institut Curie) : "Mechanics of blastocyst morphogenesis".

4 décembre 2017. Jean-Léon Maitre (Institut Curie) : "Mechanics of blastocyst morphogenesis"

Sauf mention contraire, les séminaires et les soutenances se déroulent à 11h30 en salle 454A du bâtiment Condorcet.


Mechanics of blastocyst morphogenesis

Jean-Léon Maitre, Institut Curie

Lundi 4 décembre 2017, 11H30, Salle 454, Bâtiment Condorcet

During pre-implantation development, the mammalian embryo forms the blastocyst, which will implant into the uterus. The architecture of the blastocyst is essential to the specification of the first mammalian lineages and to the implantation of the embryo. Consisting of an epithelium enveloping a fluid-filled cavity and the inner cell mass, the blastocyst is sculpted by a succession of morphogenetic events. These deformations result from the changes in the forces and mechanical properties of the tissue composing the embryo. Using microaspiration, live-imaging, genetics and theoretical modelling, we study the biophysical and cellular changes leading to the formation of the blastocyst. In particular, we uncover the crucial role of acto-myosin contractility, which generates periodic waves of contractions, compacts the embryo, controls the position of cells within the embryo and influences fate specification.


Contact : Équipe séminaires / Seminar team - Published on / Publié le 27 novembre 2017


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