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Accueil du site > Seminars > Séminaires 2018 > Séminaire MSC 454A. 12 mars 2018. Raphael Clement. IBDM. Mechanics of cell contacts during tissue morphogenesis..

Séminaire MSC 454A. 12 mars 2018. Raphael Clement. IBDM. Mechanics of cell contacts during tissue morphogenesis.

Unless otherwise stated, seminars and defences take place at 11:30 in room 454A of Condorcet building.


Tissue shape changes can be achieved by the local generation of contractile forces at cell contacts. Understanding how such forces are converted into cell shape changes is essential to our understanding of tissue morphogenesis. To that end we analyzed in vivo the deformation dynamics of cell contacts resulting from both endogenous forces (Myosin-II contractile activity) and external forces (optical tweezers). It is consistent with a simple viscoelastic framework, with internal dissipation occurring on the minute timescale. Interestingly this timescale is commensurate with that of force generation by Myosin-II itself, allowing efficient remodelling of cell contacts. We also show that the turnover of Actin filaments, by renewing the mechanical structure of the cell, participates in dissipation and therefore affects the reversibility of deformations. Overall our results argue that tissue morphogenesis requires coordination between force generation and dissipation.


Contact : Équipe séminaires / Seminar team - Published on / Publié le 21 February


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