Home page > Seminars > Séminaires théorie > Theory Club Wednesday May 30 2018 at 12:30pm in room 646A. Milos Knezevic: "Mechanical tuning of synaptic patterns enhances immune discriminations".
Theory Club Wednesday May 30 2018 at 12:30pm in room 646A. Milos Knezevic: "Mechanical tuning of synaptic patterns enhances immune discriminations"
Unless otherwise stated, seminars and defences take place at 11:30 in room 454A of Condorcet building.
Mechanical tuning of synaptic patterns enhances immune discriminations
Milos Knezevic
Abstract: An immunological synapse is an adhesive intercellular junction, patterned with a variety of receptors and ligands, that forms between B cells and antigen-presenting cells (APCs) during recognition. Via synapses, B cells use mechanical pulling forces to extract recognized antigen (Ag) from APCs. Depending on its stage of development, a B cell exhibits distinct synaptic patterns and uses force at different strength and timing, which appears to lead to varied stringency of Ag affinity discrimination. We use a statistical-mechanical model to study how the experimentally observed synaptic architectures can originate from normal cytoskeletal forces coupled to lateral organization of mobile receptors, and show how this active regulation scheme, collective in nature, may enhance the efficiency and capacity of discrimination.
Wednesday May 30 at 12:30pm in room 646A
Contact : Équipe séminaires / Seminar team - Published on / Publié le 7 May 2018
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