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Home page > Seminars > Previous seminars > Séminaires 2018 > Séminaire MSC. 11 juin 2018. Peter Olmsted ( Georgetown University) : "Asymmetry, Registration, Flip-Flop, and Phase Separation in Lipid Bilayers.".

Séminaire MSC. 11 juin 2018. Peter Olmsted ( Georgetown University) : "Asymmetry, Registration, Flip-Flop, and Phase Separation in Lipid Bilayers."

Unless otherwise stated, seminars and defences take place at 11:30 in room 454A of Condorcet building.


Lipid bilayers in vivo are multicomponent mixtures that are capable of phase separation. Model studies of bilayers often demonstrate complex phase behaviour, which in most cases is symmetric across the bilayer, so that the two leaflets locally have the same phase. However, physiological bilayers have very different compositions in the two leaflets, and the environments on either side of the bilayers are often very different (pH, ionic strength, different molecular species, …). Hence there are numerous reasons to consider phase separation in which the two leaflets have different local phases and/or compositions. One can even have anti-registered phase separation, in which leaflets are locally always in different phases! I will explore the kinetics and equilibrium behaviour of these kinds of phase separation based on different levels of modeling, and discuss signatures of asymmetry and anti-registration in experiments in the literature.


Contact : Équipe séminaires / Seminar team - Published on / Publié le 15 May 2018


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