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Home page > Seminars > Séminaires théorie > Theory Club Wednesday, February 6th at 12pm in room 646A. Anne-Florence Bitbol: "Some topics in biological evolution, from the molecule to the population".

Theory Club Wednesday, February 6th at 12pm in room 646A. Anne-Florence Bitbol: "Some topics in biological evolution, from the molecule to the population"

Unless otherwise stated, seminars and defences take place at 11:30 in room 454A of Condorcet building.


Some topics in biological evolution, from the molecule to the population

Anne-Florence Bitbol

Abstract:

Mutations act at the scale of the DNA sequence, while natural selection acts at the level of function and impacts whole populations of organisms. Physics is useful to understand these processes, both at the molecular scale and at the population scale. In the first part of my talk, I will propose a physical interpretation of the "sectors" of collectively correlated amino acids that have been discovered in several protein families through statistical analyses of sequence alignments. I will show that selection acting on an additive physical property of a protein generically gives rise to a sector.  In the second part of my talk, I will focus on how microbial populations acquire resistance to antimicrobial drugs. I will discuss how alternations of presence and absence of drug can accelerate the evolution of resistance. If time permits, I will also show that antibody-mediated bacteria cross-linking in the gut can hinder the emergence of antibiotic resistance.

Wednesday, February 6th at 12pm in room 646A


Contact : Équipe séminaires / Seminar team - Published on / Publié le 28 January


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