Home page > Research topics > Influence of the rheological properties of the elastomeres on the dynamics of ambulatory drug infusion devices.
Influence of the rheological properties of the elastomeres on the dynamics of ambulatory drug infusion devices
MSC : G. Guiffant, P. Flaud, P. Perrot, J.J. Durussel.
Collaborations : J. Merckx.
Contrat : Baxter
Keywords: perfusion, rheology, elastomeres, catheters
The use of continuous ambulatory systems for drug delivery is now developing in many fields of applications: for example antibiotics in case of cystic fibrosis, analgesia after surgery. The main element of such a system is a deformable elastic balloon containing the fluid to be injected during the perfusion. The fluid is put in motion by the internal pressure P delivered by the elastic balloon. A calibrated hydraulic resistance Rh is inserted in the outflow catheter in order to ensure a prescribed flow. During the main time of the delivery of the perfusion, the internal pressure in the balloon is much higher than the venous pressure pv at the outlet permitting the flow to be as close as possible to the prescribed nominal flow: then it is an evidence that the rheological properties of the elastic material are determinant for the functioning of the system. Two different sort of elastomer are commonly used: silicones or polyisoprene with different mechanical properties thus leading to possible important discrepancy between nominal and measured flow.
Nom des membres actuels ou anciens
DURUSSEL Jean-Jacques, FLAUD Patrice, GUIFFANT Gérard, PERROT Pierre
General keyword
Teams
Keywords
If some information on this page is erroneous or missing (for instance the list of research topics), please contact the web team (lab-msc-web AT listes.sc.univ-paris-diderot.fr).
