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Nanomedicine
Nanomedicine is the medical application of nanotechnology. Nanomedicine ranges from the medical applications of nanomaterials and biological devices, to nanoelectronic biosensors, biomarkers and biomachines.
MSC : Jean-François Berret (CNRS researcher)
Current nanomedicine issues involve understanding and controlling the interactions (and toxicity) of nanoscale materials with biological body fluids, with cells and tissues. Our research focuses on tailoring nanoparticle interfaces and functionalization. In collaboration with the company SPECIFIC POLYMERS, we synthesize functional polymers that can be applied to a wide range of metallic surfaces and be supplied in large amounts. The copolymers contains multiple phosphonic acids as metal binding agents and poly(ethylene glycol) as protein resistant chains. This coating is efficient towards various metal oxide particles and substrates, including cerium, iron, titanium and aluminum oxide substrates. We have shown that such a polymer coating shows exceptional low nanoparticle uptake towards living cells and is able to prolong the lifetime of contrast agents in the blood significantly.
REFERENCES
V. Baldim, Y. Nisha, N. Bia, A. Graillot, C. Loubat, S. Singh, A.S. Karakoti and J.-F. Berret* Polymer coated cerium oxide nanoparticles as oxidoreductase-like catalysts ACS Applied Materials and Interfaces (August 2020)
M. Falahati*, F. Attar, M. Sharifi, T. Haertlé, J.-F. Berret, R. H. Khan, and A. A. Saboury A health concern regarding the protein corona, aggregation and disaggregation Biochimica and Biophysica Acta – General Subjects 1863, 971 – 991 (2019) https://doi.org/10.1016/j.bbagen.20...
V. Baldim, A. Graillot, N. Bia, C. Loubat and J.-F. Berret* Mono- versus multi-phosphonic acid based PEGylated polymers for functionalization and stabilization of metal (Ce, Fe, Ti, Al) oxide nanoparticles in biological media Advanced Materials Interfaces 1801814 (2019) https://doi.org/10.1002/admi.201801814
F. Mousseau* and J.-F. Berret* The role of surface charge in the interaction of nanoparticles with model pulmonary surfactants Soft Matter 14, 5764 – 5774 (2018) https://doi.org/10.1039/c8sm00925b
V. Baldim*, F. Bedioui, N. Mignet, I. Margaill and J.-F. Berret* The enzyme-like catalytic activity of cerium oxide nanoparticles and its dependency on Ce3+ surface area concentration Nanoscale 10, 6971 – 6980 (2018) https://doi.org/10.1039/C8NR00325D
N. Giamblanco*, G. Marletta*, A. Graillot, N. Bia, C. Loubat and J.-F. Berret* Serum protein resistant behavior of multisite-bound poly(ethylene glycol) chains onto iron oxide surfaces ACS Omega 2, 1309 – 1320 (2017) https://doi.org/10.1021/acsomega.7b00007
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