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HOG Signaling cascade dynamics in the yeast Saccharomyces cerevisiae
MSC : Agnès Miermont, Jannis Uhlendorf, Artémis Llamosi, Pascal Hersen
Cellular responses to external changes must be tightly regulated for cells to maintain their normal physiology (pH, nutrient abundance, etc). Signalling pathways convert input stimuli from the environment into biochemical outputs inside the cell which are used to regulate cellular responses. The MAP Kinase pathways (Mitogen Activated Protein Kinases) are involved in eukaryotes in several cellular processes such as stress response (JNK, P38/HOG) or the control of differentiation and proliferation processes (ERK/MAPK). In this project, we focus on the high osmolarity glycerol (HOG) pathway in the budding yeast Saccharomyces cerevisiae. This cascade is induced by an osmotic shock and is responsible for the activation by phosphorylation of the protein kinase Hog1. Even if this cascade is very well defined biologically, its dynamical properties remain unknown. Using micro-fluidic techniques combined with time-lapse fluorescent microscopy and modeling approach, we tend to better understand and control the response dynamic of this signaling pathway in fluctuating environment.
Nom des membres actuels ou anciens
HERSEN Pascal, MIERMONT Agnès, UHLENDORF Jannis, LLAMOSI Artémis
General keyword
Teams
Keywords
- Mechanics of cells and tissues, Mechanotransduction
- Out of equilibrium dynamic systems and nonlinear physics
- Microfabrication
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