Tissue Mechanics and Genetics 2018

Tissue Morphogenesis: interplay between genetics and mechanics

Workshop organized by François Graner, Stephan Grill, Pierre-François Lenne, Kaoru Sugimura

Contact tissue.mecgen2018@univ-paris-diderot.fr

Date : May 23-25, 2018, Université Paris 7 Diderot. Scroll down for details of how to get there.

Note that on May 22nd, there will be a one-day informal discussion on numerical simulations of tissue morphogenesis. Scroll down for details.

Important

This is an informal workshop open to anyone, for instance biologists, physicists or mathematicians, who are actually performing (or intend to perform soon) research to understand the interplay between genetics and mechanics in tissue morphogenesis.

Please note that participants are responsible for finding their own accommodation in Paris. We have some money to fund a few participants, with priority to young ones.

Motivations

How do cells organize to form tissues? To tackle this question, there is a need to integrate multiple aspects of morphogenesis, as genetics, biochemistry and mechanics interplay during development.

The general objective of this informal workshop is to bring together researchers interested in interdisciplinary approaches to tissue morphogenesis, in animals and plants. It aims at encouraging discussions between researchers in the field, exchange of unpublished information, and new collaborations. Together we will discuss open scientific questions and methodological challenges. The selection of participants aims at balancing the different backgrounds, laboratories and fields of research.

After the 2014 workshop devoted to experimental measurements of stresses, and the 2016 workshop devoted to theoretical models, in 2018 we will focus on the interplay between genetics and mechanics. Covered topics and methods will include :

- mechano-chemical patterning and regulation

- gene regulation of/by mechanics

- imaging and probing biochemical signaling and mechanics

- integration of genetics, biochemistry, mechanics in experiments, data analysis, theory, and numerical simulations.

Structure of the workshop

The workshop is purposely informal:

- free registration

- discussions and chalk-talks, rather than video-projections and invited speakers

At each discussion, participants will design a time-keeper and a secretary to take notes.

In order to plan the discussions as efficiently as possible, you will find here the dates of presence of all participants.

Tentative program

The exact program will be determined with the participants. As a tentative guideline, each session will be dedicated to a major theme. Each session will start by a review of the current state of the field by one of the participants, aiming at identifying key unsolved questions and bottlenecks to be discussed.

Discussions will be held from 9h to 12h and from 14h30 to 17h30, with breaks (except on Thursday).

Tuesday, May 22nd, 2018

Before the actual workshop, we will hold a one-day informal discussion on numerical simulations of tissue morphogenesis. To fulfill participants' demands, after an introduction to open questions by Alexander Fletcher, there will be a discussion on recent advances in cellular vertex and Potts models and other existing models during the morning (9h-12h) and the afternoon (14h30-17h30). We will compare techniques, whether in two or three dimensions, and discuss their perspectives. The discussion will include the comparisons with experiments, and the definitions and implementations or active stress; possibly also morphogens, polarity, dissipation.

In addition, from 14h to 14h30 there will be two parallel optional sessions : Marc Durand will animate a discussion on how to share coding and optimization practices; and Matthias Merkel will give a short tutorial on how to relate cell-level and tissue-level descriptions (for continuum models).

Evening (~18h-~22h) : welcome drink for workshop participants.

Wednesday, May 23rd, 2018

Morning (9h-12h): From genetics to mechanics. After an introduction to open questions by Romain Levayer, we will discuss the genetic regulation of mechanical patterning, morphogens, genetic control of cell mechanical properties.

Afternoon (14h30-17h30): From mechanics to genetics. After an introduction to open questions by Chii Jou Chan, we will discuss gene regulation by mechanics, mechanotransduction, feedback of tissue shape on its own morphogenesis.

Thursday, May 24th, 2018

Morning (9h-13h): experimental methodology. After an introduction to open questions by Sham Tlili, we will discuss experimental techniques devoted to measuring and correlating information from genetics and mechanics, including kinematics, forces, polarity, spatial maps of gene expression and protein distribution.

Afternoon : No plenary session. You may rest, self-organise discussion on technical issues, or do mutual presentation of your research.

Friday, May 25th, 2018

Morning (9h-12h): modeling. After an introduction to open questions by Karen Alim, we will discuss how numerical and analytical models contribute to the understanding of interplay between genetics and mechanics.

Afternoon (14h30-17h30): Perspectives. After an introduction to open questions by Beatriz Gonçalves, we will begin the session with a short discussion of integrating genetics and mechanics into evo-devo. Then, we will have a group discussion on current and future research directions, requirements for new techniques, perspectives of bilateral or multilateral collaborations.

Registration

Registration is now closed.

Dates and places

The workshop will be held in University Paris 7 “Denis Diderot”, Paris Rive Gauche campus, Condorcet A building, 6th floor, room 646A.

Please read carefully the following explanations and print the maps.

The “Paris Rive Gauche” campus of University Paris 7 "Denis Diderot" is in the south-east of Paris (XIIIth district), between the National Library and the ringroad. It can be accessed from the station “Bibliothèque François-Mitterrand” of RER C or subway line 14, by buses 89, 62, 64, 325, and by the “velib” bicycles.

The Condorcet building is close to the Seine river and has a distinct orange-brown color. From subway line 14, RER C or bus 89 (arrêt “Bibliothèque François Mitterrand”) go to the Seine by walking downhill, then turn right. See the map of the district (bottom left) and the detailed map of the building (bottom right). On these maps, green dots label the building entrances.

Caution: these streets are new. Some commercial maps or GPS systems have not yet incorporated them. Watt street, which is almost identical to Alice Domon and Léonie Duquet, is normally always indicated.

Caution again: this building is subdivided into two subunits, Condorcet A and Condorcet B, which are connected only at the ground floor (as well as a footbridge at 4th floor and another one at 6th floor).

Caution again: at night it is only possible to leave this building through the guarded door on 10 rue Alice Domon and Léonie Duquet, close to the river.

Practical details

Participants are responsible for finding their own accommodation in Paris, or south-east suburb such as Ivry. We have some money to fund a few participants, with priority to young ones.

Wifi for academic participants: eduroam is available at the venue, but you must register at your home institution in advance; if you need an alternative wifi, please let us know.

Participants should check whether they need a visa to enter France. We can provide invitation letters upon request.

Lunch and coffee in the middle of sessions will be provided for free. Lunch will be at University Restaurant Buffon. There will be a self-service starter buffet followed by a main dish. Dessert and wine can be ordered at your own expense. The coffee is included in lunch. If you want a modification of dish (eg for dietary, allergy or personal reasons, including vegetarians), please notify us before April 30th at latest. If you don't want to eat there, you can go to nearby restaurants, or bring your own food. In that case, please notify us before April 30th at latest.

On Tuesday May 22nd, 18h-22h approximately, we will have a welcome party at the workshop site. If you can, bring some specialties ! The local organiser will order drinks. The organisers will reserve a nearby restaurant for dinner on Wednesday May 23rd if requested.

Contact

 
tissue-mecgen2018.txt · Dernière modification: 2018/05/16 15:48 par fgraner
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