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Séminaires MSC
"Matière et Systèmes Complexes"

                      

Lundi 5 novembre 2007 à 11h30
Bâtiment Condorcet, 4ème étage, salle 454 A.


Matthieu Piel

(Institut Curie, Paris) 



Micro-Tools for Cell Biologists: cell division, cell motility and cell morhpogenesis in controlled geometries

In vivo, cells have to face a complex micro-environment, whereas, in vitro, even if cells are more amenable to experimentation, the culture conditions are often over-simplified if not completely artefactual. Recent progress in micro-fabrication
makes it easy enough for a Cell Biologist to develop in his lab micro-tools that can achieve an intermediary level of complexity: more parameters can be finely controlled - cell adhesion, substrate physical properties, cell shape, chemical
micro-environment – at timescales and length scales relevant for biological processes. We explored these new technical possibilities through several collaborations with chemists, physicists and biologists studying
various experimental systems
from fission yeast morphogenesis to dendritic cells motility; I will also present recent results in our current main field of investigation: mechanisms controlling the division axis in mammalian cells.