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Séminaire MSC
"Matière et Systèmes Complexes"

                      

Lundi 17 mars 2008 à 11h30
Bâtiment Condorcet, 4ème étage, salle 454 A.

Yu-Li Wang
(University of Massachussets
)


Searching for Unified Mechanisms in Cellular Mechanical Interactions

 

Many cellular functions involve mechanical interactions on the surface as well as in the cytoplasm, yet the nature of these forces and interactions remain poorly understood.  We have addressed this problem with imaging, microfabrication, polymer material, micromanipulation, and mathematical modeling approaches.  Creative applications of polyacrylamide have allowed the detection of forces both inside and outside cells, as well as photo-activated manipulations of substrate rigidity.  In addition, imaging of focal adhesion dynamics under different conditions lead to a common model for the detection of forces, rigidity, and migration, based on lateral structural shear at focal adhesions.  Using mathematical modeling, we further demonstrated that a wide range of cell shapes and migration behaviors may be explained by a simple feedback control circuit.