"Matière et Systèmes Complexes"
17 mars 2008 à 11h30
Bâtiment Condorcet, 4ème étage, salle 454 A.
(University of Massachussets)
Searching for Unified Mechanisms in Cellular Mechanical Interactions
cellular functions involve mechanical
interactions on the surface as well as in the cytoplasm, yet the nature
these forces and interactions remain poorly understood.
We have addressed this problem with imaging,
microfabrication, polymer material, micromanipulation, and mathematical
modeling approaches. Creative
applications of polyacrylamide have allowed the detection of forces
and outside cells, as well as photo-activated manipulations of
addition, imaging of focal
adhesion dynamics under different conditions lead to a common model for
detection of forces, rigidity, and migration, based on lateral
at focal adhesions. Using
modeling, we further demonstrated that a wide range of cell shapes and
migration behaviors may be explained by a simple feedback control